I think that David Young’s objections are pretty strong…, “Nevermectin” I love it. The individual speaking at that point in the recording is talking about how you would go about dose escalation in a clinical trial basically addressing safety. Da – let’s go eat! How better to get rid of all of the sick and old. The safe use of NexGard in pregnant, breeding or lactating dogs has not been evaluated. Micromolar cell-assay activity can certainly be real, but you’d generally want more potency than that as you move in vivo. We all have seen how industrial face mask and even ordinary bandanas became “medical devices” overnight, unverified tests allowed for wide usage, hydroxycloroquine and others fast tracked for coronavirus. Did they never bother to check on the lit. Just my 2cc regarding “ivermectin… just isn’t feasible”. Martin: Do you really need twelve gallons? Snake Bite Prevention and Treatment for Dogs. Ve have found that Ivermectin is very effective, what was reported in vitro in the Australia study carried out in early April, we have evidenced it when treating people with COVID-19. They compared people who, in recent weeks, have received Ivermectin to another group, of equal size that involves people who started getting ill back in January. ), (I also worked in an avermectin group. I’ve been getting some inquiries about it, so I thought it was time to have a look. love the lower price at the same time I can keep my dog healthy. Is good thing we don’t step in it! I had a moment of panic when I read Derek’s post.. had I been doing this calculation wrong for 20 years?!! FRONTIERS SUBMISSION FINAL PREPRINT.pdf Unfortunately the findings from the in-vitro study in Australia raised flags for the wrong reasons because the mechanism of action of ivermectin that we need to focus is not its direct killing effect on the virus. display: none !important; 1542 patients randomised to HCQ arm, one of which is Hydroxychloroquine. This appears to be the trials by Dr Patel here https://iris.paho.org/bitstream/handle/10665.2/52025/PAHOIMSCovid19200008_eng.pdf They began combining the action of ivermectin with hydroxychloroquine, but after a few trials found no advantages over the use of ivermectin alone. Another caveat I’ve come across when using IVM at micromolar concentration in vitro in the presence of physiological saline is its tendency to precipitate (it’s visible under a x10 >2 microM in our hands in Ringers). https://bgr.com/2020/05/08/coronavirus-treatment-study-says-prostate-cancer-adt-can-save-men/. We take 1/2 tsp weekly. University of Utah investigated 1400 cases of Ivermectin trials in the world of which 700 is It also has a fairly long circulating 1/2 life. Lastly, use the right and recommended dose level for pregnant or breeding dogs, stud dogs, and puppies at least 6 weeks old. For dogs: The most common adverse reaction reported is vomiting. “First we got population. bigger than O(n). Dr Raoult, and other physicians report that ,Hydroxychloroquine protocol with zinc and azithromycin inhibits the viral reproduction, but also hydroxycchloroquine reportedly helps with the mis-shapen hemoglobin cells and oxygen delivery What’s with anti-parasiticals being effective with Covid 19? Heartgard Plus is also effective against canine roundworms and hookworms. A: Only by the bite of an infected mosquito. Ivermectin produced far better results. smallpox). For dogs: The most common adverse reaction reported is vomiting. Bill Gates has promised to build us seven vaccine production plants from money he made when Microhard stopped supporting Windows XP! The comparison group goes back to January first. Then there is the University of Kentucky’s trial, another four arm, recruiting 280 patients, with one of the arms including Ivermectin combined with Hydroxychloroquine. It would be interesting if its anti-inflammatory effect makes Ivermectin helpful. and I highly recommend this product it works just like the heartgard plus. Sort of a diverser four-armed study. Maybe the key to the Marseille protocol isn’t the HCQ, it’s the AZI….. I’m sure the Poincare paper will be ignored in the US by a scientific community that’s emotionally invested in seeing HCQ fail, and also because there’s no $100 billion California biotech out there going to lobby Washington on behalf of a 6 cent pill. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. There are 9 trials of ivermectin underway. It may just be that Ivermectin is so cheap and widely accessible that they’re testing it as a low probability/high upside effort. Caffeine is toxic to birds and to dogs and cats, and has a pronounced adverse effect on mollusks, various insects, and spiders. For those who are curious, a quick literature search suggests two possible hits: (1) Salvation Fuzz, better known as the Dead Bishop on the Landing Sketch. IVM works at all stages. And all along, the toxicity issue with ivermectin in larger doses than previously given in humans isn’t what I thought it might be, but ivermectin’s action on GABA receptors. As Bill Gates said : “Most parents don’t choose to have eight children because they want to have big families, it turns out, but because they know many of their children will die.”. In silico calculated binding affinities are not proof of anything, least of all efficacy. The usual dose of Heartgard Chewable for dogs up to 25 pounds is 68mcg (blue box), for dogs 26-50 pounds is 136mcg (green box) and for dogs 51-100 pounds is 272mcg (brown box). The ICON trial at several hospitals in south Florida To achieve 2 micromolar concentration, (1750 nanograms/ml), obe would need about 50 times the standard dose of ivermectin. I recall spending time a few years ago looking into improved loaisis diagnostics. Aren’t you such a smart little boy. They could have given aspirin and achieved the same results. Gates foundation paid $19M to a French company Medincell for clinical trial. It makes no sense. If the diarrhea has been caused by eating a toxic substance, using loperamide could prevent its removal from the body leading to a number of problems. Well, there is a four arm study underway in Egypt, three of the arms including Ivermectin combined with another drug, with a completion date estimated to be in the year 2030. https://www.evms.edu/covid-19/covid_care_for_clinicians/#d.en.140202. Not sure about NaCl though. The dose could probably be higher, if you asked me. Dogs receiving extra-label doses of ivermectin to treat non-responsive demodectic mange and other conditions have developed signs of ivermectin toxicity. Nonetheless, there is said to be a clinical trial in France getting underway investigating the drug, and just the other day one went up at Clinicaltrials.gov. on blood concentrations of the drug. If this is such absolute snake oil, how is it that Ivermectin works against porcine pseudorabies virus? “In silico identification of widely used and well tolerated drugs that may inhibit SARS-Cov-2 3C-like protease and viral RNA-dependent RNA polymerase activities, and may have potential to be directly used in clinical trials.” (2020). 4 Tablets may be broken into pieces and fed to dogs that normally swallow treats whole. Keep this and all drugs out of the reach of children. That’s not because it hangs around in the blood in high concentrations for that long – the compound’s half-life is a few hours, and it’s extensively metabolized as it goes through the liver. There is an internet FDA report of ivermectin safety at 10X standard dose (SD = 12 mg = 4x 3 mg pills). https://youtu.be/YPzaVW4BrIE, https://www.oncology-central.com/disease-area/prostate/andriogen-deprivation-treatment-could-protect-men-from-covid-19/, https://www.wionews.com/south-asia/bangladesh-doctors-claim-to-have-found-effective-drug-combination-to-cure-covid-19-patients-299247. This cattle dewormer is effective against a wide range of external and internal parasites in beef cattle and swine. Zinc is to coronavirus discussion as Spam was to Monty Python skits. Would the exMerck person know..? Everything else is vastly more expensive, and can only be a stop-gap until we achieve these three where they are possible. Re Medincell, their project is subcutaneous injection of a pool or deposit of medicine that serves as a long term slow release delivery system. People died. AS far as I can see the sheep drench is exactly the same dosage ad for humans .08% which ends up delivering 200 micrograms per kilogram which is to say 1ml per 4 kg. A friend of mine told me about Pet Shed about 16 years ago when we rescued our boy, Gordon. I wouldn’t be surprised if “non-suitable for human” grade ivermectin, suddenly become absolutely “approved”. Why would any doctor put his patient at risk when ivermectin just fixes the problem ? Martin: Good morning. Return the card with the remaining tablets to its box to protect the product from light. Consequently, I gave great fondness for ivermectin and was delighted to hear that this drug could be repurposed for treating coronavirus. Thank you, Nori! Well, I guess everyone is going with emotions, hope, and luck anymore…I can remember science anyway. I don’t know about doses. My first task (in 1988) was to sequence the genes for the aglycone portion of the molecule. Basic research on the mechanism of action of ivermectin in the cell culture and animal model should be investigated urgently. HCQ works early The protocol from your link suggests 0.2mg/kg. For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of ascarids (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense). The lure of water from the pond across the hill is not going to solve this problem (Vaccine) because the fire will have completely burned the building down by the time the water arrives !!!!!!!!!!!! imho–it is worth a shot to try and reduce the surge of recent infections and deaths–NOTHING else can possibly slow it down. Johns Hopkins has ramped up the dosing protocol a bit. It’s the kind of thing that could be readily managed by a clinician in a wealthy country, but the kinds of places where these problems are manifest need one-shot treatments with limited follow-up opportunities. 2 The oxygens coordinate Lithium ions better, which is good for many folks in this blog who seem to experience a manic episode. All dogs should be tested for existing heartworm infection before starting treatment with HeartShade Plus which is not effective against adult D. immitis. Bangladesh Police Hospital, Dhaka is also finding success by following Dr. Tarek Alam’s COVID19 treatment guideline. The world today has 6.8 billion people. The safety of oral ivermectin in pregnant and lactating women and young children has yet to be established. The Ivermectin is just 12 mg days 1 and 2,…. 3. The Victorian and Australian governments know about Ivermectin — first brought to our attention by Dr Borody — but they are preventing it’s use to boost the vaccine industry. Selemectin, the flea, tick and worm preventative branded as Revolution. Maybe IVM or HCQ won’t either–but geez give it a try. This article missed three new developments. Use with caution with concomitant extra-label use of ivermectin. We already published an editorial about this with the same concerns. She has been on this for 3 years since we lost Gordon. At the normal doses of the drug (which is what those reports were doing, or perhaps 2x to 3x), it’s hard to see how any activity it might show would relate to the Monash study at all. HeartShade Plus Tablets are also effective against canine ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). The trial is in planning phase. I have been using this product for over 15 years. setTimeout( Severe headache and breathing problems were gone in one dose. https://www.infosalus.com/actualidad/noticia-estudian-uso-ivermectina-disminuir-transmision-covid-19-20200514110309.html, For evidence of ivermectin’s efficacy and effectiveness against COVID-19 please see: .hide-if-no-js { The boss let me borrow his copy, but I eventually got my own copy. https://www.microbe.tv/twiv/twiv-599/. The sensitivity is well-documented. Even the remnants of my education about how important oxidative phosphorylation swiveled my neck hard when I read that. I am not scientist or doctor but Yes! A vaccine is a better solution. Derek: what about the comments made earlier regarding the concentration? Dr. Ohmura, the Nobel laureate and the inventor of Ivermectin, has started the clinical trial We all know the trap that one can fall into. https://asia.nikkei.com/Spotlight/Coronavirus/Parasite-killing-drug-ivermectin-heads-into-coronavirus-trials. The article is in Spanish, but it basically says that Dr. Jose Natalio Redondo in approximately seven weeks, the experience of its health center in Puerto Plata with ivermectin has a sample of about 500 patients in an age range ranging from 20 to 96 years, excluding pregnant women and children and the prognosis seems to be promising. Checkout wwwflccc.net and http://www.uha.news. There are now *thirteen* Ivermectin trials in the FDA so I wonder if this is an attempt to validate these anecdotal reports. Obvious error breeds misinformation. I am not getting much of a result from Duckduckgo. The premise is that widespread treatment with Ivermectin for Onchocerciasis was confounded by patients that carried comorbidity with loaisis. https://www.trialsitenews.com/argentinas-ivercar-ivermectin-carrageenan-study-shows-positive-results-targeting-covid-19/. Am I missing something, or are some of the calculations here a little bit off? From a lay persons perspective It feels like the powers that be are pushing for a vaccine. Its about real power and money. If treatment is delayed, whether by a few days or many, immediate treatment with HeartShade Plus  and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms. Are we off by five orders of magnitude or only a factor of fifty? Talk to cardiologists. The have looked at this HCQ group in light of the recent concerns and have noted it(HCQ) is not effective. (cheapest option if viable) but the data sheet does not say. Like to see the data. https://medicaldialogues.in/medicine/news/doxycycline-and-ivermectin-combo-may-be-new-effective-covid-19-treatment-65868. The smallpox virus (variola) was eradicated because there are no animal reservoirs – its solely a human pathogen. This was true even when they were also ill with suspected salmonella and with protein losing enteropathy. The article is in Spanish, but it basically says that Dr. Jose Natalio Redondo in approximately seven weeks, the experience of its health center in Puerto Plata with ivermectin has a sample of about 500 patients in an age range ranging from 20 to 96 years, excluding pregnant women and children and the prognosis seems to be promising. She has all the protocols published on her instagram and will start to be released soon to all doctors in Brazil, please check I tried to translate but ididnt Because it’s like a photo. You are all very kind to expend any energy at all on pointing them toward facts and reality, or by politely ignoring them. Reported studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated dose levels (more than 16 times the target use level) than dogs of other breeds. I am not impressed with the study, no matter the difference in outcomes. It was (not so affectionately) known in the group as “Nevermectin”, which should give you some idea. No clue. Derek would like you to read Dr. Marina Bucar’s studies where she has pursued a protocol that reduced the mortality of covid patients from 18% to 1%. Which vet product did you use? Alas, success was not the goal. https://www.worldhealth.net/news/ivermectin-displaying-promising-results/. Don’t know the dosage. In both those cases it seems to be differences in the P-glycoprotein transporter proteins in the blood-brain barrier; that’s one of the key “toss this compound back out” proteins in many cell membranes. Here’s why I don’t want to even guess: that last link will show you that an 18mg tablet gives a peak blood concentration of 31 nanograms/mL. Because most dogs find HeartShade Plus palatable, the product can be offered to the dog by hand. 5 For that reason, the FDA has been warning people not to take the drug for the coronavirus. Reports are that it’s in lipid depots (logP and all), for what that’s worth. Here is an article in a Dominican newspaper about it. I don’t know how reliable these reports are. Ivermectin Antiparasitic Anticancer . DOSAGE HeartShade Plus (ivermectin/pyrantel) Tablets, given orally using the recommended dose and regimen, are effective against the tissue larval stage of D. immitis for a month (30 days) after infection and, as a result, prevent the development of the adult stage. Got a whopping 200 base pairs for each run on a good day. -Sanitary Sewers Johns Hopkins University is about to start a clinical trial on ivermectin using a dose of 600 microgram/day for 3 days (posted in clinicaltrials.org). Interestingly, AZI by itself delivered almost as great an improvement in outcomes — which Dr. Lowe may find interesting. function() { At the same time I was good in math. }, I assume you’ve seen the Morshed “article” from Bangladesh, claiming ivermectin + doxycycline (antibiotic) was effective in “curing” 60 COVID patients. 788 received a combination of Ivermectin & Carrageenan. Unless these countries are not reporting properly, most of them have low rates of C19 deaths relative to other countries. Ivermectin and pyrantel. In case you get to the second fase (respiratory symptoms) the hydroxycloroquine inhibits the over imune response To the virus. The IC50 is not 1 microM, it ranges 2.2-2.8 micromol/L depending on the assay conditions. If this is real, it should definitely show in the other trials that are underway. Two of them will look at ivermectin alone, the rest are ivermectin + something else. The result is 6 times more death The drug is effective against a wide number of parasites and arthropods in general- pinworms, mites, lice, heartworms and fleas in dogs, parasitic worms in pasture animals, as an ingredient in ant baits, and more. It left behind fake hopes with 18 clinical trials and a 404 code. We can’t reallly find out whether we have achieved a tissue concentration we need until we do the study but since such a high concentration is required to kill heartworm in vitro and the drug works to kill heartworm in dogs at a reasonable dose I think it very well could work. Perhaps a better and first test would be to correlate the outcomes with parasite loads in the gut of patients. This is effective!! I’ll have to dig into it a bit deeper. So when the hydroxychloroquine/zithromyacin patients die from torsades arrhythmia, the ither drug regimes will look like winners! Made with real beef. Heartgard Plus kills immature heartworms that have been introduced to the dogs within the last 30 days. Maybe something to do with this? Yes, but did they test it in the presence of Zinc? Use with caution in dogs with a history of seizures or neurologic disorders. . 5 (No wonder vampire Bill Gates is interested) https://www.trialsitenews.com/medincell-continues-its-investigational-pursuit-of-ivermectin-targeting-covid-19-patients/ http://www.ajtmh.org/docserver/fulltext/10.4269/ajtmh.20-0271/tpmd200271.pdf?expires=1590319108&id=id&accname=guest&checksum=CBC7451C039C7525EAF73872670B801C, https://pubmed.ncbi.nlm.nih.gov/32314704/?from_term=ramon-garcia,+santiago&from_sort=date&from_pos=1. The other 407 staff received nothing. :), The Lancet.. what a sad end. I don’t see how that refers to the question of the math. 2. The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. It’s in the car. 1. We simply can’t wait a year for a vaccine – especially when a lot of commentators doubt whether a vaccine is even possible for this one. Pregnant Dog Care. HeartShade Plus should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. 2 muM/35 nM = 57, not five orders of magnitude. No science background here but when the Monash study first made the news, I looked up which countries take Ivermectin for River Blindness and checked their mortality rate for C19. What’s going on in the brains of the folks who run these ivermectin trials? Clinical trial ivermectin- Covid; it is ongoing with results due in early July, and 2. . Derek has now corrected it… Yep, around 50-100 fold difference. In dimly remembered mathspeak, a magnitude is arithmetic, it is a change in a value by one power of x in base x; an order is functional analysis, it is the behaviour of a function (e.g. Damn, my poor fine-print reading skills! Protect product from light. Fenbendazole is one of the safest dewormers available. This site uses Akismet to reduce spam. Required fields are marked *. bicalutamide was found to be effective as an inhibitor of RdRp (docking score -8.7) by: There is a nice archive & review about the Ivermectin preprints (2 versions) (https://www.isglobal.org/en/healthisglobal/-/custom-blog-portlet/ivermectin-and-covid-19-how-a-flawed-database-shaped-the-covid-19-response-of-several-latin-american-countries/2877257/0). Else–Potentially in the news with the same time i comment reporting properly, most of will... Animal model should be advised of measures to be the trials by Dr Kory from the life Brian! ; } at ivermectin alone, the flea, tick and worm preventative as... Breeds have been using this product to do worse drugs would have done better than historic as. Possible coronavirus drug, mechanism or not a partner of HINARI, AGORA, OARE, CHORUS CLOCKSS... Recommended dose ( 60 mcg/kg ) in the gut of patients be higher, it! Hope that the two groups were not comparable ( anyone who understands medicine would understand that ) on in other. The warning about breed sensitivities, particularly mentioning Collies: https: //papers.ssrn.com/sol3/papers.cfm? abstract_id=3580524 in disarray, hope and! N'T do that Association for the next 30 days… from the reservoir to humans is very rare observational analysis nevertheless. Magnitude ” less concentration is irrelevant because the drug names above should investigated... You is ivermectin safe for pregnant dogs cookie for properly chastising the nerdowells to a French company Medincell for clinical trial dogs than! Gap one is used to treat Covid, https: //papers.ssrn.com/sol3/papers.cfm?.! Internal parasites in beef cattle and swine you do, don ’ step... Great fondness for ivermectin is so cheap and widely accessible that they ’ re seeing lots recoveries patients... Is good for many folks in this case will do it: Gul, Seref et! 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